Cinetica Media En Excel - Como Calcular La Temperatura

= LN(D1 / COUNTA(A2:A100)) (COUNTA counts your temperature entries) In cell F1, enter:

= EXP(-10000 / B2) Copy this down for all rows. In a new cell (e.g., D1), enter:

= 10000 / E1 In cell G1, enter:

(reliable):

Use:

1. Introduction Mean Kinetic Temperature (MKT) is a simplified way to express the overall effect of temperature fluctuations during storage or transit of products, particularly pharmaceuticals, food, and other temperature-sensitive goods. It is defined as a single calculated temperature that represents the cumulative thermal stress experienced by a product over a time period.

[ MKT = \frac10000\ln\left( \frac\sum e^-10000 / T_in \right) ] Assume you have temperature readings in °C in column A (rows 2 to 100, for example). Step 1: Convert Celsius to Kelvin In cell B2, enter:

[ MKT = \frac-\Delta H/R\ln\left( \frac\sum_i=1^n e^-\Delta H / R \cdot T_in \right) ]

The MKT is always higher than the arithmetic mean temperature unless the temperature is perfectly constant. It is calculated using the , which describes the relationship between temperature and reaction rates. 2. The MKT Formula According to the ICH Q1A (R2) guideline (stability testing of new drug substances and products), the MKT is calculated as:

= SUM(C2:C100) In cell E1, enter:

= A2 + 273.15 Copy this formula down for all temperature readings. In cell C2, enter: